1. Selene (Black Queen – Hellfire Club) – Marvel
Selene – better known as the Black Queen of the Hellfire Club – is at least 17,000 years old and continuously wreaks havoc on the Marvel Universe, mostly by terrorizing the X-Men. She’s featured as the boss of one of Gambit’s stages in Spider-Man & the X-Men in Arcade’s Revenge, so you know she’s obnoxious.
Mutant power: Life-draining psychic vampire, flame manipulation
2. Star Sapphire – DC
The original Star Sapphire had several remarkable powers that included the use of a violet Power Ring (like the Green Lantern Corps). The main thing to know about Star Sapphire is that she is a group, a corps just like the Green Lantern. The group is possessed by the Star Sapphire gem, which is attracted to worthy females who are in love with Hal Jordan. Remember folks, stalking and harrassment are crimes, no matter if you are a gem or not.
Super power: Violet Power Ring possession, force blasts, protective shield, flight
3. Lady Deathstrike – Marvel
Yeah, so Yuriko Oyama has an adamantium-bonded skeleton similar to Wolverine’s. The reason for this? Because she wanted to have it. It wasn’t that she had it forced on her; no, she asked Spiral to do the process because she wanted to be able to kill Wolverine, who she thought stole the theories and ideas on the adamantium process. Receiving cybernetic implants as well, Yuriko has hunted Wolverine for decades.
Mutant power: Superhuman strength, speed, stamina, durability and agility; unbreakable skeleton laced with adamantium and 10 claws made of adamantium; and a cybernetic healing factor.
4. Talia ah Gul – DC
The daughter of Ra’s ah Gul, Talia has carried on her father’s life of crime and destruction. She’s covertly worked to take over Gotham City, injured or killed numerous people and lead the notorious League of Assassins. Her saving grace is the fact that she married Bruce Wayne and produced an heir, Damien Wayne. Eventually, she disowns Damien after realizing that he would always oppose her after taking up his father’s cause. Motherly love this is not.
Super power: Enhanced longevity, genius-level intelligence, superior marksmanship and swordsmanship
5. Mystique – Marvel
There isn’t much that Mystique hasn’t done. In several realities, she has been the cause of assassinations of key figures that leads to the downfall of that reality (see: Days of Future Past) and has betrayed quite a few people in her path. Given that she’s able to shapeshift at will into whomever she wants, Mystique has used that power to further her own agenda and goals. Usually, those goals are in line with the Brotherhood of Evil.
Mutant power: Shapeshifting